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CARDIOVASCULAR SYSTEM › CARDIAC THERAPY › VASODILATORS USED IN CARDIAC DISEASES › Other vasodilators used in cardiac diseases
itramin tosilate, combinations
C01DX51
Forms & Strengths
- Oral tablets containing itramin tosilate in fixed-dose combinations
Adult Dosing
- 1 to 2 tablets orally 2-3 times daily as directed for angina prophylaxis
- Titrate dose based on clinical response and hemodynamic tolerance
Pediatric Dosing
- Safety and efficacy in pediatric patients have not been established
Indications
- Prophylaxis and long-term management of angina pectoris
- Adjunctive treatment in chronic coronary artery disease
Mechanism of Action
- Acts as a vasodilator by relaxing vascular smooth muscle
- Reduces myocardial oxygen demand by decreasing preload and afterload via nitric oxide pathway
Contraindications
- Known hypersensitivity to itramin tosilate or nitrates
- Severe hypotension or uncorrected hypovolemia
- Concomitant use with phosphodiesterase-5 (PDE-5) inhibitors like sildenafil
- Acute circulatory failure, shock, or cardiogenic shock
Adverse Reactions
- Transient throbbing headaches
- Dizziness and lightheadedness
- Orthostatic hypotension and reflex tachycardia
- Flushing and localized skin redness
- Nausea and gastrointestinal distress
Drug Interactions
- Profound enhancement of hypotensive effects with PDE-5 inhibitors (e.g., sildenafil, tadalafil)
- Additive vasodilation and hypotension with antihypertensive drugs, beta-blockers, and calcium channel blockers
- Potentiation of hypotensive effects with acute alcohol consumption
- Potential decreased efficacy when co-administered with certain sympathomimetics
Curated Content: Needs Vetting Before Put to Clinical Use