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CARDIOVASCULAR SYSTEM › CARDIAC THERAPY › VASODILATORS USED IN CARDIAC DISEASES › Other vasodilators used in cardiac diseases
prenylamine, combinations
C01DX52
Forms & Strengths
- Tablets: 50mg, 100mg
- Injectable: 25mg/mL, 50mg/mL
Adult Dosing
- Angina pectoris: 50-100mg orally 2-3 times daily
- Hypertension: 50-100mg orally 2-3 times daily
Pediatric Dosing
- Not established for pediatric use
- Contraindicated in children due to lack of safety data
Indications
- Angina pectoris
- Hypertension
- Coronary heart disease
Mechanism of Action
- Calcium channel blocker
- Inhibits influx of calcium ions into cardiac muscle and vascular smooth muscle
- Dilates coronary arteries and peripheral arteries
Contraindications
- Hypersensitivity to prenylamine
- Severe left ventricular dysfunction
- Cardiogenic shock
- Children
Adverse Reactions
- Hypotension
- Dizziness
- Headache
- Nausea
- Vomiting
- Constipation
Drug Interactions
- Beta blockers: increased risk of hypotension and bradycardia
- Nitrates: increased risk of hypotension
- Digitalis glycosides: increased risk of digitalis toxicity
- Quinidine: increased risk of quinidine toxicity
Curated Content: Needs Vetting Before Put to Clinical Use