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CARDIOVASCULAR SYSTEM › CARDIAC THERAPY › VASODILATORS USED IN CARDIAC DISEASES › Other vasodilators used in cardiac diseases
oxyfedrine, combinations
C01DX53
Forms & Strengths
- Oral tablets containing oxyfedrine combined with complementary cardiovascular agents
- Strengths vary by specific regional pharmaceutical formulation
Adult Dosing
- Typically 8 mg to 16 mg orally three times daily
- Dosage adjusted based on clinical response and heart rate tolerance
Pediatric Dosing
- Safety and efficacy in pediatric patients not established
- Use in children is generally not recommended
Indications
- Management of chronic stable angina pectoris
- Adjunctive treatment for functional cardiovascular symptoms
Mechanism of Action
- Acts as a partial beta-adrenoceptor agonist and calcium modulating agent
- Improves myocardial oxygen supply-demand balance and coronary blood flow
Contraindications
- Hypersensitivity to oxyfedrine or any combination component
- Severe tachyarrhythmias or acute myocardial infarction
- Decompensated heart failure
Adverse Reactions
- Palpitations and tachycardia
- Dizziness and headache
- Gastrointestinal upset
- Hypotension
Drug Interactions
- Enhances hypotensive effects with other antihypertensive agents
- Potential additive chronotropic or inotropic effects with beta-agonists or calcium channel blockers
Curated Content: Needs Vetting Before Put to Clinical Use