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CARDIOVASCULAR SYSTEM › CARDIAC THERAPY › OTHER CARDIAC PREPARATIONS › Other cardiac preparations
tiracizine
C01EB11
Forms & Strengths
- Tablets: 5mg, 10mg, 20mg
- Injectable solution: 10mg/mL
Adult Dosing
- Angina pectoris: 10-20mg orally 3-4 times daily
- Hypertension: 5-10mg orally 2-3 times daily
- Acute myocardial infarction: 10mg IV bolus, followed by 5-10mg orally 3-4 times daily
Pediatric Dosing
- Safety and efficacy not established in pediatric patients
Indications
- Treatment of angina pectoris
- Treatment of hypertension
- Management of acute myocardial infarction
Mechanism of Action
- Calcium channel blocker, inhibits influx of calcium ions into cardiac and smooth muscle cells
- Dilates coronary and peripheral arteries, reducing cardiac afterload and oxygen demand
Contraindications
- Hypersensitivity to tiracizine or other calcium channel blockers
- Severe left ventricular dysfunction
- Cardiogenic shock
- Sick sinus syndrome or second- or third-degree AV block (unless paced)
Adverse Reactions
- Headache
- Dizziness
- Hypotension
- Peripheral edema
- Constipation
- Nausea
- Flushing
Drug Interactions
- Beta blockers: increased risk of hypotension and AV block
- Nitrates: increased risk of hypotension
- Cimetidine: increased tiracizine levels
- Theophylline: decreased theophylline levels
Curated Content: Needs Vetting Before Put to Clinical Use