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CARDIOVASCULAR SYSTEM › CARDIAC THERAPY › OTHER CARDIAC PREPARATIONS › Other cardiac preparations
trimetazidine
C01EB15
Forms & Strengths
- 35mg tablets
- 60mg modified-release tablets
Adult Dosing
- 1 tablet of 35mg, 3 times a day
- 1 tablet of 60mg modified-release, twice a day
Pediatric Dosing
- Not recommended for children under 18 years
Indications
- Angina pectoris
- Chronic stable angina
- Asymmetric septal hypertrophy
Mechanism of Action
- Optimizes myocardial glucose utilization through inhibition of long-chain 3-ketoacyl CoA thiolase (3-KAT)
- Increases myocardial glucose uptake and utilization
Contraindications
- Severe renal impairment
- Parkinson’s disease
- Severe hyporthroidism
- Pregnancy and lactation
Adverse Reactions
- Dizziness
- Nausea
- Headache
- Fatigue
- Diarrhea
Drug Interactions
- Increased risk of hypokalemia with potassium-depleting diuretics
- Increased risk of hyperkalemia with potassium-sparing diuretics
- Interaction with grapefruit or grapefruit juice is not established
Curated Content: Needs Vetting Before Put to Clinical Use