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CARDIOVASCULAR SYSTEM › CARDIAC THERAPY › OTHER CARDIAC PREPARATIONS › Other cardiac preparations
acoramidis
C01EB25
Forms & Strengths
- Tablets: 5mg, 10mg, 20mg, 50mg
- Oral solution: 1mg/mL
Adult Dosing
- Heart failure: Initially 5mg twice daily, titrate up to 10mg twice daily
- Hypertension: Initially 5mg once daily, titrate up to 20mg once daily
Pediatric Dosing
- Safety and efficacy not established in pediatric patients under 18 years old
Indications
- Treatment of heart failure (NYHA Class II-IV)
- Treatment of hypertension
Mechanism of Action
- Directly binds to and inhibits soluble guanylate cyclase
- Increases cyclic guanosine monophosphate (cGMP) levels
- Produces vasodilation and decreases blood pressure
Contraindications
- Hypersensitivity to acoramidis
- Concomitant use with PDE5 inhibitors (e.g., sildenafil, tadalafil)
- Concomitant use with nitrates or nitric oxide donors
Adverse Reactions
- Headache
- Dizziness
- Hypotension
- Renal impairment
- Increased creatinine levels
Drug Interactions
- PDE5 inhibitors: increased risk of hypotension
- Nitrates/nitric oxide donors: increased risk of hypotension
- CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin): increased acoramidis levels
- CYP3A4 inducers (e.g., rifampin): decreased acoramidis levels
Curated Content: Needs Vetting Before Put to Clinical Use