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CARDIOVASCULAR SYSTEM › ANTIHYPERTENSIVES › ANTIADRENERGIC AGENTS, CENTRALLY ACTING › Rauwolfia alkaloids
bietaserpine
C02AA07
Adult Dosing
- Initial dose: 4mg once daily, Maintenance dose: 2-8mg once daily
Pediatric Dosing
- Not established for patients under 18 years old
Indications
- Hypertension
- Chronic heart failure
Mechanism of Action
- Selective beta-1 adrenergic receptor blocker with additional alpha-1 adrenergic receptor blocking activity
Contraindications
- Severe bradycardia
- Second or third degree AV block
- Hypersensitivity to the drug
Adverse Reactions
- Dizziness
- Headache
- Fatigue
- Bradycardia
- Hypotension
Drug Interactions
- Verapamil and diltiazem: increased risk of AV block
- Beta-2 agonists: potential for mutual inhibition of therapeutic effects
Curated Content: Needs Vetting Before Put to Clinical Use