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combinations of rauwolfia alkoloids, combinations

C02AA53

Forms & Strengths

Tablets: 1mg reserpine with 0.1mg hyoscine
Capsules: 2mg rauwolfia extract with 0.2mg other alkaloids
Injectable: not commonly used
Combination products vary in strengths and compositions

Adult Dosing

Initial dose: 0.25-0.5mg reserpine or equivalent daily
Maintenance dose: 0.1-1mg reserpine or equivalent daily
Titrate dosage based on patient response and blood pressure control
Maximum dose: typically not to exceed 2mg daily

Pediatric Dosing

Not established for children
Use with caution in pediatric patients due to lack of data
Start with low doses and monitor closely

Indications

Treatment of mild to moderate hypertension
Used in combination for additive antihypertensive effects
Sometimes used for anxiety and schizophrenia in specific contexts

Mechanism of Action

Reserpine depletes catecholamines and serotonin in the brain and adrenergic nerve endings
Rauwolfia alkaloids decrease sympathetic tone and lower blood pressure
Central and peripheral effects contribute to antihypertensive action

Contraindications

Hypersensitivity to rauwolfia alkaloids or any component
Depression, particularly with suicidal tendencies
Active peptic ulcer
Parkinson’s disease

Adverse Reactions

Drowsiness and sedation
Nasal congestion
Dry mouth
Gastrointestinal upset
Bradycardia and hypotension
Parkinsonian symptoms
Psychiatric disturbances, including depression

Drug Interactions

Other antihypertensive agents may increase the risk of hypotension
MAO inhibitors can cause hypertensive crisis
Barbiturates and other CNS depressants may increase sedative effects
Tricyclic antidepressants may interact with rauwolfia to worsen depression

Curated Content: Needs Vetting Before Put to Clinical Use