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CARDIOVASCULAR SYSTEM › ANTIHYPERTENSIVES › ANTIADRENERGIC AGENTS, PERIPHERALLY ACTING › Guanidine derivatives
guanoxan
C02CC03
Forms & Strengths
- Oral tablets: 10 mg
- Oral tablets: 20 mg
Adult Dosing
- Initial: 10 mg orally once or twice daily
- Titration: Increase by 10 mg at weekly intervals based on blood pressure response
- Maintenance: 20 to 60 mg daily in divided doses
Pediatric Dosing
- Safety and efficacy in pediatric patients have not been established
Indications
- Management of moderate to severe hypertension
Mechanism of Action
- Adrenergic neuron blocking agent
- Depletes norepinephrine stores in sympathetic nerve endings
- Decreases peripheral vascular resistance and lowers blood pressure
Contraindications
- Known hypersensitivity to guanoxan
- Pheochromocytoma
- Concomitant use with monoamine oxidase inhibitors (MAOIs)
- Congestive heart failure not secondary to hypertension
Adverse Reactions
- Orthostatic hypotension
- Dizziness and lightheadedness
- Fatigue and weakness
- Diarrhea
- Nasal congestion
- Bradycardia
- Impotence
Drug Interactions
- Monoamine oxidase inhibitors (MAOIs): May precipitate hypertensive crisis or reverse the antihypertensive effect
- Tricyclic antidepressants: May block the antihypertensive effect of guanoxan
- Direct-acting sympathomimetics (e.g., norepinephrine): May show enhanced pressor response
- General anesthetics: May cause severe hypotension when used concomitantly
- Other antihypertensive agents: May result in additive hypotensive effects
Curated Content: Needs Vetting Before Put to Clinical Use