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CARDIOVASCULAR SYSTEM › ANTIHYPERTENSIVES › ANTIADRENERGIC AGENTS, PERIPHERALLY ACTING › Guanidine derivatives
debrisoquine
C02CC04
Forms & Strengths
- 25mg tablets
- 50mg tablets
Adult Dosing
- Initial dose: 10-25mg orally three times a day
- Maintenance dose: 25-50mg orally three times a day
- Dose adjustment based on blood pressure response
Pediatric Dosing
- Not recommended for use in pediatric patients
- Limited data available
Indications
- Treatment of hypertension
- Management of angina pectoris
Mechanism of Action
- Inhibits the uptake of norepinephrine into sympathetic nerve endings
- Increases the concentration of norepinephrine in the synaptic cleft
- Decreases peripheral resistance and lowers blood pressure
Contraindications
- Hypersensitivity to debrisoquine
- Severe coronary insufficiency
- Cardiogenic shock
- Concomitant use with MAO inhibitors
Adverse Reactions
- Orthostatic hypotension
- Dizziness
- Headache
- Fatigue
- Nausea and vomiting
Drug Interactions
- Concomitant use with other antihypertensive agents may increase the risk of hypotension
- MAO inhibitors may increase the risk of hypertensive crisis
- Tricyclic antidepressants may increase the risk of arrhythmias
Curated Content: Needs Vetting Before Put to Clinical Use