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CARDIOVASCULAR SYSTEM › ANTIHYPERTENSIVES › ARTERIOLAR SMOOTH MUSCLE, AGENTS ACTING ON › Pyrimidine derivatives
minoxidil
C02DC01
Forms & Strengths
- 2% topical solution
- 5% topical foam
- 10mg oral tablets
Adult Dosing
- Apply 1ml of 2% solution to affected area twice daily
- Apply 1g of 5% foam to affected area twice daily
- Oral: 2.5-10mg once daily, titrate to response
Pediatric Dosing
- Topical: not recommended for children under 18 years
- Oral: limited data available, use with caution
Indications
- Treatment of severe hypertension
- Male and female pattern baldness
- Alopecia areata
Mechanism of Action
- Direct vasodilation, opening of potassium channels
- Increasing cutaneous blood flow, promoting hair growth
Contraindications
- Hypersensitivity to minoxidil or components
- Pheochromocytoma
- Congestive heart failure
Adverse Reactions
- Hypertrichosis
- Tachycardia
- Hypotension
- Fluid retention
- Contact dermatitis
Drug Interactions
- Concomitant guanethidine: increased risk of hypotension
- Concomitant hydralazine: enhanced antihypertensive effect
- Increased theophylline levels with concurrent use
Curated Content: Needs Vetting Before Put to Clinical Use