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bosentan

C02KX01

Forms & Strengths

Tablets: 62.5mg, 125mg
Film-coated tablets

Adult Dosing

Initial: 62.5mg twice daily for 4 weeks
Maintenance: 125mg twice daily
Dosage adjustments for liver function

Pediatric Dosing

Limited data available
Not recommended for children under 12 years old

Indications

Pulmonary arterial hypertension (PAH)
Digital ulcers in systemic sclerosis

Mechanism of Action

Dual endothelin receptor antagonist
Blocks ETA and ETB receptors
Reduces vascular resistance and pulmonary pressure

Contraindications

Hypersensitivity to bosentan
Severe liver dysfunction
Pregnancy

Adverse Reactions

Headache
Flushing
Palpitations
Nasopharyngitis
Elevated liver enzymes

Drug Interactions

Cyclosporine: increased bosentan levels
Glyburide: increased risk of liver injury
Hormonal contraceptives: reduced efficacy
Warfarin: increased INR

Curated Content: Needs Vetting Before Put to Clinical Use