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CARDIOVASCULAR SYSTEM › ANTIHYPERTENSIVES › ANTIHYPERTENSIVES AND DIURETICS IN COMBINATION › Rauwolfia alkaloids and diuretics in combination
reserpine and diuretics
C02LA01
Forms & Strengths
- Tablets: reserpine 0.1mg, hydrochlorothiazide 25mg
- Tablets: reserpine 0.25mg, hydrochlorothiazide 50mg
- Capsules: reserpine 0.25mg, chlorthalidone 25mg
Adult Dosing
- Initial dose: 0.25mg reserpine, 50mg hydrochlorothiazide orally once daily
- Maintenance dose: 0.1-0.25mg reserpine, 25-50mg hydrochlorothiazide orally once daily
Pediatric Dosing
- Not recommended for children under 12 years old
- For children over 12 years, use with caution and under medical supervision
Indications
- Treatment of hypertension
- Treatment of congestive heart failure
- Treatment of edema associated with heart failure, hepatic cirrhosis, or nephrotic syndrome
Mechanism of Action
- Reserpine depletes catecholamines and serotonin, reducing sympathetic tone and blood pressure
- Diuretic component (e.g. hydrochlorothiazide, chlorthalidone) promotes sodium and water excretion, reducing fluid volume and blood pressure
Contraindications
- Hypersensitivity to reserpine or diuretics
- Active peptic ulcer disease
- Untreated pheochromocytoma
- Severe renal disease
Adverse Reactions
- Reserpine: nasal congestion, drowsiness, insomnia, depression, parkinsonian symptoms
- Diuretic component: hypokalemia, hypochloremia, hyponatremia, hyperglycemia, hyperuricemia, azotemia
Drug Interactions
- Increased hypotension with other antihypertensive agents
- Increased sedation with CNS depressants (e.g. barbiturates, benzodiazepines)
- Reduced efficacy with NSAIDs
- Increased hypokalemia with corticosteroids, amphotericin B
Curated Content: Needs Vetting Before Put to Clinical Use