← Search & browse all drugs
CARDIOVASCULAR SYSTEM › ANTIHYPERTENSIVES › ANTIHYPERTENSIVES AND DIURETICS IN COMBINATION › Rauwolfia alkaloids and diuretics in combination
bietaserpine and diuretics
C02LA07
Forms & Strengths
- Bietaserpine 5mg + Hydrochlorothiazide 25mg tablets
- Bietaserpine 5mg + Hydrochlorothiazide 50mg tablets
- Bietaserpine 10mg + Hydrochlorothiazide 25mg tablets
Adult Dosing
- Initial dose: 5mg/25mg once daily
- Maintenance dose: 5mg/50mg once daily
- Maximum dose: 10mg/50mg once daily
Pediatric Dosing
- Not recommended for children under 18 years old
- Use with caution in pediatric patients with renal impairment
Indications
- Treatment of hypertension
- Treatment of edema associated with heart failure
- Treatment of renal hypertension
Mechanism of Action
- Bietaserpine: selective alpha-1 adrenergic receptor antagonist
- Hydrochlorothiazide: thiazide diuretic, inhibits sodium reabsorption in the distal convoluted tubule
Contraindications
- Hypersensitivity to bietaserpine, hydrochlorothiazide, or other thiazides
- Anuria or severe renal impairment
- Hepatic coma or severe liver dysfunction
Adverse Reactions
- Dizziness, headache, fatigue
- Orthostatic hypotension, syncope
- Nausea, vomiting, diarrhea
- Impotence, decreased libido
Drug Interactions
- Potentiation of orthostatic hypotension with other antihypertensive agents
- Increased risk of hypokalemia with other diuretics or digitalis glycosides
- Decreased efficacy with NSAIDs, including COX-2 inhibitors
Curated Content: Needs Vetting Before Put to Clinical Use