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CARDIOVASCULAR SYSTEM › ANTIHYPERTENSIVES › ANTIHYPERTENSIVES AND DIURETICS IN COMBINATION › Rauwolfia alkaloids and diuretics in combination
reserpine and diuretics, combinations with psycholeptics
C02LA71
Forms & Strengths
- Reserpine 0.1-0.25mg with hydrochlorothiazide 25-50mg
- Reserpine 0.25mg with chlorthiazide 25-50mg
- Tablets
- Combination packs
Adult Dosing
- Initially 0.5-1 tablet daily
- Maintenance 0.5-2 tablets daily
- Maximum 4 tablets daily in divided doses
Pediatric Dosing
- Not recommended for children under 12 years
- For children over 12 years, same as adult dosing
Indications
- Mild to moderate hypertension
- Edema associated with congestive heart failure
Mechanism of Action
- Reserpine depletes catecholamines and serotonin
- Diuretic reduces sodium and water retention
Contraindications
- Hypersensitivity to reserpine or diuretics
- Depression
- Parkinson's disease
- Peptic ulcer
Adverse Reactions
- Drowsiness
- Dizziness
- Nausea
- Diarrhea
- Hypotension
Drug Interactions
- Increased hypotension with other antihypertensives
- Increased sedation with CNS depressants
- Reduced efficacy with NSAIDs
Curated Content: Needs Vetting Before Put to Clinical Use