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CARDIOVASCULAR SYSTEM › DIURETICS › LOW-CEILING DIURETICS, THIAZIDES › Thiazides, plain
chlorothiazide
C03AA04
Forms & Strengths
- Tablets: 250mg, 500mg
- Oral suspension: 250mg/5mL
Adult Dosing
- Edema: 500mg-1000mg daily
- Hypertension: 250mg-500mg daily
- Diuresis: 500mg-1000mg as single dose
Pediatric Dosing
- Edema: 10-20mg/kg daily in 1-2 doses
- Hypertension: not recommended under 6 months
Indications
- Treatment of edema associated with congestive heart failure
- Treatment of edema associated with renal disease
- Treatment of hypertension
Mechanism of Action
- Inhibits sodium reabsorption in the distal convoluted tubule
- Increases urine production
Contraindications
- Hypersensitivity to sulfonamides
- Anuria or severe renal impairment
- Severe hepatic dysfunction
Adverse Reactions
- Hypokalemia
- Hyponatremia
- Hyperuricemia
- Skin rash
- Photosensitivity
Drug Interactions
- Lithium: diuretic-induced lithium toxicity
- Digitalis: diuretic-induced hypokalemia
- Non-steroidal anti-inflammatory agents: reduced diuretic effect
Curated Content: Needs Vetting Before Put to Clinical Use