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CARDIOVASCULAR SYSTEM › DIURETICS › LOW-CEILING DIURETICS, THIAZIDES › Thiazides, plain
polythiazide
C03AA05
Forms & Strengths
- Oral tablets: 1 mg, 2 mg, 4 mg
Adult Dosing
- Hypertension: 2 mg to 4 mg orally once daily
- Edema: 1 mg to 4 mg orally once daily, up to 8 mg daily in severe cases
Pediatric Dosing
- Safety and efficacy in pediatric patients have not been established
Indications
- Management of hypertension either as sole agent or to enhance efficacy of other antihypertensives
- Adjunctive therapy in edema associated with congestive heart failure, hepatic cirrhosis, and corticosteroid/estrogen therapy
Mechanism of Action
- Inhibits sodium chloride reabsorption in the distal convoluted tubules, leading to increased excretion of sodium, chloride, and water
Contraindications
- Anuria
- Hypersensitivity to polythiazide or other sulfonamide-derived drugs
Adverse Reactions
- Hypokalemia, hyponatremia, hypomagnesemia, hypercalcemia
- Hyperglycemia, hyperuricemia, dyslipidemia
- Orthostatic hypotension, dizziness, vertigo
- Photosensitivity, rash, urticaria
Drug Interactions
- Lithium: decreased renal clearance, increasing risk of lithium toxicity
- Antihypertensive agents: additive hypotensive effect
- Corticosteroids and ACTH: increased risk of severe hypokalemia
- Nonsteroidal anti-inflammatory drugs (NSAIDs): may attenuate diuretic and antihypertensive efficacy
Curated Content: Needs Vetting Before Put to Clinical Use