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CARDIOVASCULAR SYSTEM › DIURETICS › LOW-CEILING DIURETICS, THIAZIDES › Thiazides, plain
trichlormethiazide
C03AA06
Forms & Strengths
- Tablets: 2 mg, 4 mg, 5 mg
- Oral solution: 5 mg/mL
Adult Dosing
- Edema: 2-4 mg daily, in single or divided doses
- Hypertension: 2-4 mg daily, may be increased to 8-12 mg in some cases
Pediatric Dosing
- Not recommended for children under 6 months
- Children 6 months and older: 0.2-0.4 mg/kg/day, in single or divided doses
Indications
- Treatment of edema associated with congestive heart failure
- Treatment of edema associated with hepatic cirrhosis
- Treatment of hypertension
- Treatment of nephrotic syndrome
Mechanism of Action
- Inhibits sodium reabsorption in the distal convoluted tubule
- Increases renal excretion of sodium, chloride, and water
- Decreases blood volume and venous return to the heart
Contraindications
- Anuria or renal failure
- Hypersensitivity to thiazide diuretics
- Hyperuricemia or gout
Adverse Reactions
- Dizziness
- Headache
- Fatigue
- Nausea and vomiting
- Hypokalemia
- Increased uric acid levels
Drug Interactions
- May potentiate effects of lithium and increase risk of lithium toxicity
- May decrease effects of insulin and oral hypoglycemic agents
- May increase risk of hypokalemia with concomitant use of digitalis
Curated Content: Needs Vetting Before Put to Clinical Use