← Search & browse all drugs

cyclopenthiazide

C03AA07

Forms & Strengths

Tablets: 0.25 mg, 0.5 mg, 1 mg

Adult Dosing

Hypertension: 0.25 mg to 0.5 mg orally once daily in the morning.
Edema: 0.5 mg to 1 mg orally daily or intermittently.

Pediatric Dosing

Safety and efficacy in pediatric patients not established; use generally avoided or individualized based on clinical expert guidance.

Indications

Management of hypertension
Treatment of edema associated with congestive heart failure, hepatic cirrhosis, or corticosteroid/estrogen therapy

Mechanism of Action

Thiazide diuretic that inhibits sodium and chloride reabsorption at the early distal convoluted tubule in the kidneys
Increases excretion of sodium, chloride, water, and potassium, leading to reduced blood volume and decreased peripheral vascular resistance

Contraindications

Anuria
Hypersensitivity to thiazides or sulfonamide-derived drugs
Severe renal or hepatic impairment
Refractory hypokalemia, hyponatremia, or hypercalcemia

Adverse Reactions

Hypokalemia, hyponatremia, hypomagnesemia, hypercalcemia
Hyperuricemia and gout exacerbation
Hyperglycemia and dyslipidemia
Orthostatic hypotension, dizziness, and fatigue
Photosensitivity and skin rashes

Drug Interactions

Lithium: Decreased renal clearance, increasing risk of lithium toxicity
Antihypertensive agents: Synergistic blood pressure reduction
NSAIDs: May attenuate the diuretic and antihypertensive effects and increase renal impairment risk
Corticosteroids and ACTH: Increased risk of severe hypokalemia
Digitalis glycosides: Increased toxicity risk if thiazide-induced hypokalemia occurs

Curated Content: Needs Vetting Before Put to Clinical Use