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CARDIOVASCULAR SYSTEM › DIURETICS › LOW-CEILING DIURETICS, THIAZIDES › Thiazides, plain
cyclothiazide
C03AA09
Adult Dosing
- Edema: 1 to 2 mg orally once daily or every other day, titrated based on response
- Hypertension: 0.5 to 2 mg orally once daily
Pediatric Dosing
- Safety and efficacy in pediatric patients have not been established
Indications
- Management of edema associated with congestive heart failure, cirrhosis, and corticosteroid or estrogen therapy
- Management of hypertension either alone or as an adjunct to other antihypertensive drugs
Mechanism of Action
- Thiazide diuretic that inhibits sodium and chloride reabsorption in the distal convoluted tubules, increasing excretion of sodium, chloride, water, and potassium
Contraindications
- Anuria
- Hypersensitivity to thiazides or sulfonamide-derived drugs
- Severe renal impairment or hepatic coma
Adverse Reactions
- Hypokalemia
- Hyponatremia
- Hyperuricemia
- Hyperglycemia
- Hypotension
- Dizziness
- Photosensitivity
Drug Interactions
- Lithium: Decreases lithium clearance, increasing risk of lithium toxicity
- Antihypertensive agents: Enhances hypotensive effects
- NSAIDs: May attenuate the diuretic, natriuretic, and antihypertensive effects of thiazides
- Corticosteroids: Increases risk of severe hypokalemia
Curated Content: Needs Vetting Before Put to Clinical Use