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CARDIOVASCULAR SYSTEM › DIURETICS › LOW-CEILING DIURETICS, THIAZIDES › Thiazides, plain
mebutizide
C03AA13
Adult Dosing
- 10-20mg daily in 1-2 divided doses
- Maximum dose: 40mg daily
Indications
- Mild to moderate hypertension
- Edema associated with congestive heart failure
Mechanism of Action
- Thiazide-like diuretic that inhibits sodium reabsorption in the distal convoluted tubule
- Increases urinary excretion of sodium, chloride, potassium, and water
Contraindications
- Hypersensitivity to mebutizide or thiazide diuretics
- Anuria or severe kidney impairment
- Hypercalcemia
Adverse Reactions
- Hypokalemia
- Hypotension
- Hyperglycemia
- Increased uric acid levels
- Impotence
Drug Interactions
- Potassium-sparing diuretics: may increase risk of hyperkalemia
- Lithium: may increase lithium toxicity
- Nonsteroidal anti-inflammatory drugs (NSAIDs): may decrease diuretic efficacy
Curated Content: Needs Vetting Before Put to Clinical Use