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chlortalidone

C03BA04

Forms & Strengths

Oral tablet: 15 mg
Oral tablet: 25 mg
Oral tablet: 50 mg
Oral tablet: 100 mg

Adult Dosing

Hypertension: 12.5 mg to 25 mg orally once daily; may increase up to 50 mg daily if needed
Edema: 50 mg to 100 mg orally once daily, or 100 mg 3 times per week

Pediatric Dosing

Safety and efficacy not established in pediatric patients
Off-label (Edema/Hypertension): 0.2 to 0.5 mg/kg orally once daily, titrated up to 1 mg/kg/day max

Indications

Management of hypertension, as monotherapy or in combination with other antihypertensives
Management of edema associated with congestive heart failure, hepatic cirrhosis, or corticosteroid/estrogen therapy

Mechanism of Action

Inhibits sodium and chloride reabsorption in the cortical diluting segment of the distal convoluted tubule
Increases excretion of sodium, chloride, and water, while decreasing calcium excretion and increasing potassium and magnesium excretion

Contraindications

Anuria
Hypersensitivity to chlortalidone or other sulfonamide-derived drugs
Severe electrolyte depletion states

Adverse Reactions

Hypokalemia, hyponatremia, hypomagnesemia, hypercalcemia
Hyperuricemia and gout exacerbation
Hyperglycemia and impaired glucose tolerance
Orthostatic hypotension, dizziness, and fatigue
Photosensitivity and rash

Drug Interactions

Lithium: Decreased renal clearance, increasing risk of lithium toxicity
NSAIDs: May attenuate the antihypertensive and diuretic efficacy of chlortalidone
Other antihypertensive agents: Synergistic blood pressure lowering effects
Corticosteroids or ACTH: Increased risk of severe hypokalemia

Curated Content: Needs Vetting Before Put to Clinical Use