← Search & browse all drugs
CARDIOVASCULAR SYSTEM › DIURETICS › LOW-CEILING DIURETICS, EXCL. THIAZIDES › Sulfonamides, plain
mefruside
C03BA05
Forms & Strengths
- Tablets: 25mg
- Tablets: 50mg
Adult Dosing
- 25-50mg orally once daily
- Dose titration based on patient response
- Maximum dose: 100mg/day
Pediatric Dosing
- Not recommended for children under 12 years old
- For children over 12 years, use adult dosing
Indications
- Treatment of essential hypertension
- Treatment of edema associated with congestive heart failure
- Treatment of edema associated with nephrotic syndrome
Mechanism of Action
- Inhibits sodium and chloride reabsorption in the distal convoluted tubule
- Increases renal excretion of sodium, chloride, and water
- Reduces peripheral vascular resistance
Contraindications
- Hypersensitivity to mefruside or other sulfonamide derivatives
- Severe renal impairment (creatinine clearance <30ml/min)
- Anuria or hepatic coma
Adverse Reactions
- Hypokalemia
- Hypotension
- Hyperuricemia
- Gastrointestinal disturbances
- Rash or other skin reactions
Drug Interactions
- Increases effects of other antihypertensive agents
- May decrease effects of ACE inhibitors
- Concomitant use with NSAIDs may decrease diuretic effects
- May increase lithium toxicity
Curated Content: Needs Vetting Before Put to Clinical Use