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CARDIOVASCULAR SYSTEM › DIURETICS › LOW-CEILING DIURETICS, EXCL. THIAZIDES › Sulfonamides, plain
metolazone
C03BA08
Forms & Strengths
- Tablets: 2.5mg, 5mg, 10mg
- Zaroxolyn: 2.5mg, 5mg, 10mg
- Generic: 2.5mg, 5mg, 10mg
Adult Dosing
- Edema: 2.5-5mg daily, max 20mg daily
- Hypertension: 2.5-5mg daily, max 10mg daily
Pediatric Dosing
- Not established for children under 18 years
Indications
- Mild to moderate essential hypertension
- Edema associated with heart failure, nephrotic syndrome, or cirrhosis
Mechanism of Action
- Inhibits sodium reabsorption at distal convoluted tubule
- Increases renal excretion of sodium, chloride, and water
Contraindications
- Anuria
- Severe hepatic disease
- Severe renal disease (GFR < 30mL/min)
Adverse Reactions
- Dizziness
- Lightheadedness
- Headache
- Fatigue
- Nausea
- Vomiting
- Hypokalemia
- Hyponatremia
Drug Interactions
- Loop diuretics: increased risk of hypokalemia
- Lithium: increased risk of lithium toxicity
- Digitalis: increased risk of digitalis toxicity
- Other antihypertensive agents: additive effect
Curated Content: Needs Vetting Before Put to Clinical Use