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CARDIOVASCULAR SYSTEM › DIURETICS › LOW-CEILING DIURETICS, EXCL. THIAZIDES › Sulfonamides, plain
meticrane
C03BA09
Adult Dosing
- Hypertension: 5 mg orally once daily
- Edema: 5 to 10 mg orally once daily or every other day
Pediatric Dosing
- Safety and efficacy in pediatric patients not established
Indications
- Management of hypertension
- Treatment of edema associated with congestive heart failure, hepatic cirrhosis, and corticosteroid or estrogen therapy
Mechanism of Action
- Sulfonamide-derived thiazide-like diuretic that inhibits sodium and chloride reabsorption at the distal renal tubules
- Increases excretion of sodium, water, potassium, and hydrogen ions
Contraindications
- Anuria
- Hypersensitivity to meticrane, other sulfonamide-derived drugs, or thiazide diuretics
- Severe hepatic coma or electrolyte depletion states
Adverse Reactions
- Hypokalemia, hyponatremia, hypomagnesemia, and hypercalcemia
- Hyperuricemia and precipitation of gout
- Hyperglycemia and dyslipidemia
- Orthostatic hypotension, dizziness, and fatigue
- Photosensitivity and rash
Drug Interactions
- Lithium: decreased renal clearance, increasing the risk of lithium toxicity
- Antihypertensive agents: additive hypotensive effects
- NSAIDs: may attenuate the diuretic, natriuretic, and antihypertensive effects
- Corticosteroids or ACTH: increased risk of severe hypokalemia
Curated Content: Needs Vetting Before Put to Clinical Use