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CARDIOVASCULAR SYSTEM › DIURETICS › LOW-CEILING DIURETICS, EXCL. THIAZIDES › Sulfonamides, plain
clorexolone, combinations with psycholeptics
C03BA82
Forms & Strengths
- Tablets: 5mg + 2.5mg
- Oral solution: 1.25mg + 0.625mg/5mL
Adult Dosing
- Hypertension: 5mg + 2.5mg once daily, titrate up to 10mg + 5mg
- Edema: 5mg + 2.5mg once daily, adjust based on diuretic response
Pediatric Dosing
- Safety and efficacy not established in pediatric patients under 18 years
- Use with caution in pediatric patients with edema or hypertension
Indications
- Mild to moderate hypertension
- Edema associated with congestive heart failure
- Edema associated with nephrotic syndrome
Mechanism of Action
- Clorexolone: aldosterone antagonist, increases sodium and water excretion
- Psycholeptic component: enhances the antihypertensive and diuretic effects
Contraindications
- Anuria or acute kidney injury
- Hypersensitivity to clorexolone or psycholeptic agents
- Severe hepatic dysfunction
Adverse Reactions
- Hyperkalemia
- Hypokalemia
- Hypotension
- Dizziness
- Headache
- Gastrointestinal disturbances
Drug Interactions
- Potassium supplements: increased risk of hyperkalemia
- ACE inhibitors: increased risk of hyperkalemia and hypotension
- Lithium: decreased lithium clearance, increased risk of lithium toxicity
Curated Content: Needs Vetting Before Put to Clinical Use