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CARDIOVASCULAR SYSTEM › DIURETICS › LOW-CEILING DIURETICS, EXCL. THIAZIDES › Sulfonamides and potassium in combination
clopamide and potassium
C03BB03
Forms & Strengths
- Tablets: clopamide 5mg and potassium 300mg
- Tablets: clopamide 10mg and potassium 600mg
Adult Dosing
- 1-2 tablets daily, with maintenance dose of 1 tablet daily
- Titrate dose based on patient response, not to exceed 4 tablets daily
Pediatric Dosing
- Not recommended for children under 18 years
- Use with caution in elderly patients due to increased risk of hypokalemia
Indications
- Mild to moderate hypertension
- Edema associated with congestive heart failure
- Edema associated with nephrotic syndrome
Mechanism of Action
- Clopamide inhibits sodium reabsorption in the distal convoluted tubule
- Potassium conserves potassium and counteracts hypokalemia
Contraindications
- Severe renal impairment
- Hyperkalemia
- Hypersensitivity to clopamide or sulfonamides
Adverse Reactions
- Hypokalemia
- Hyperkalemia
- Dry mouth
- Fatigue
- Dizziness
- Gastrointestinal upset
Drug Interactions
- NSAIDs may decrease diuretic efficacy
- Corticosteroids may enhance hypokalemia
- Digitalis glycosides may increase risk of arrhythmias with hypokalemia
Curated Content: Needs Vetting Before Put to Clinical Use