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CARDIOVASCULAR SYSTEM › DIURETICS › LOW-CEILING DIURETICS, EXCL. THIAZIDES › Other low-ceiling diuretics
cicletanine
C03BX03
Forms & Strengths
- Tablets: 50mg, 100mg
- Oral solution: 50mg/5mL
Adult Dosing
- Hypertension: 50-100mg once daily
- Edema: 100-200mg once daily
Pediatric Dosing
- Not established for pediatric use
Indications
- Treatment of hypertension
- Treatment of edema associated with congestive heart failure
- Treatment of edema associated with nephrotic syndrome
Mechanism of Action
- Antagonizes aldosterone receptors in renal tubules
- Increases sodium and water excretion
- Vasodilatory properties
Contraindications
- Hypersensitivity to cicletanine
- Anuria or severe renal impairment
- Hyperkalemia
Adverse Reactions
- Dizziness
- Headache
- Fatigue
- Nausea
- Diarrhea
- Increased urination
Drug Interactions
- Potentiates effects of other antihypertensives
- Increases risk of hyperkalemia with potassium-sparing diuretics
- May reduce efficacy of lithium
Curated Content: Needs Vetting Before Put to Clinical Use