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CARDIOVASCULAR SYSTEM › DIURETICS › HIGH-CEILING DIURETICS › Sulfonamides, plain
furosemide
C03CA01
Forms & Strengths
- Tablets: 20mg, 40mg, 80mg
- Oral solution: 10mg/mL, 40mg/5mL
- Injectable solution: 10mg/mL
Adult Dosing
- Edema: 20-80mg PO q6-12h, max 600mg/day
- Hypertension: 40-80mg PO q12h
- Acute pulmonary edema: 40mg IV bolus
Pediatric Dosing
- Neonates: 1-2mg/kg IV/PO q12-24h
- Infants/children: 1-2mg/kg PO q6-12h, max 6mg/kg/day
Indications
- Edema associated with heart failure
- Hepatic cirrhosis
- Nephrotic syndrome
- Hypertension
- Acute pulmonary edema
Mechanism of Action
- Inhibits sodium and chloride reabsorption in the ascending loop of Henle
- Increases urine production by reducing water reabsorption
Contraindications
- Severe hypokalemia
- Dehydration
- Hypersensitivity to furosemide or sulfonamides
Adverse Reactions
- Hypokalemia
- Hypotension
- Dehydration
- Nausea
- Dizziness
- Ototoxicity (high doses)
Drug Interactions
- Potentiates effects of antihypertensives
- Reduces efficacy of aminoglycosides
- Increases toxicity of cisplatin
- Interacts with NSAIDs to reduce diuretic effect
Curated Content: Needs Vetting Before Put to Clinical Use