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CARDIOVASCULAR SYSTEM › DIURETICS › HIGH-CEILING DIURETICS › Sulfonamides and potassium in combination
furosemide and potassium
C03CB01
Forms & Strengths
- Tablets: 20-80 mg furosemide with 8.7-30.8 mg potassium
- Injection: 10 mg/mL furosemide with potassium
- Oral solution: 10-40 mg furosemide with potassium per 5 mL
Adult Dosing
- Edema: 20-80 mg PO once, titrate to effect
- Hypertension: 40 mg PO twice daily
- Acute pulmonary edema: 40-80 mg IV, repeat in 1 hour if needed
Pediatric Dosing
- Premature infants: 1-2 mg/kg/dose IV, IM, or PO every 12-24 hours
- Full-term infants: 1-2 mg/kg/dose IV, IM, or PO every 8-12 hours
- Children: 1-3 mg/kg/dose IV, IM, or PO every 6-12 hours
Indications
- Edema associated with congestive heart failure
- Hypertension
- Edema associated with hepatic or renal disease
- Acute pulmonary edema
- Nephrotic syndrome
Mechanism of Action
- Inhibits Na-K-2Cl cotransporter in the thick ascending limb of the loop of Henle
- Increases sodium, chloride, potassium, and water excretion
- Potassium sparing effect due to potassium component
Contraindications
- Anuria
- Hypersensitivity to furosemide or sulfonylureas
- Severe electrolyte depletion
- Hepatic coma
Adverse Reactions
- Hypokalemia
- Hypotension
- Dehydration
- Ototoxicity
- Nephrocalcinosis
- Pancreatitis
Drug Interactions
- Cisplatin: increased risk of ototoxicity
- Aminoglycosides: increased risk of nephrotoxicity and ototoxicity
- ACE inhibitors: increased risk of hypotension and hyperkalemia
- Cholestyramine: decreased furosemide absorption
- Digoxin: increased risk of digitalis toxicity
Curated Content: Needs Vetting Before Put to Clinical Use