← Search & browse all drugs
CARDIOVASCULAR SYSTEM › DIURETICS › DIURETICS AND POTASSIUM-SPARING AGENTS IN COMBINATION › Low-ceiling diuretics and potassium-sparing agents
butizide and potassium-sparing agents
C03EA14
Forms & Strengths
- Tablets: Butizide 5mg + Potassium-sparing agent
- Tablets: Butizide 10mg + Potassium-sparing agent
Adult Dosing
- Hypertension: 1-2 tablets daily
- Edema: 1-4 tablets daily
Pediatric Dosing
- Not recommended for children under 18 years old
- Use with caution in pediatric patients
Indications
- Treatment of essential hypertension
- Treatment of edema associated with congestive heart failure
- Treatment of edema associated with nephrotic syndrome
Mechanism of Action
- Butizide: inhibits sodium and chloride reabsorption in the distal convoluted tubule
- Potassium-sparing agent: blocks aldosterone effects on mineralocorticoid receptors
- Increases urinary excretion of sodium, water, and chloride
Contraindications
- Anuria or severe renal impairment
- Hypersensitivity to butizide or potassium-sparing agents
- Hyperkalemia
Adverse Reactions
- Hypokalemia
- Hyperkalemia
- Dehydration
- Gastrointestinal disturbances
- Electrolyte disturbances
Drug Interactions
- Potassium supplements or other potassium-sparing diuretics: increased risk of hyperkalemia
- Lithium: decreased lithium clearance
- NSAIDs: decreased diuretic effect and increased risk of hyperkalemia
Curated Content: Needs Vetting Before Put to Clinical Use