← Search & browse all drugs
CARDIOVASCULAR SYSTEM › PERIPHERAL VASODILATORS › PERIPHERAL VASODILATORS › Imidazoline derivatives
tolazoline
C04AB02
Adult Dosing
- Initial dose: 1mg IV, mayrepeat up to 10mg total
- Continuous infusion: 0.5-5mg/min
Pediatric Dosing
- Neonates: initial dose 1-2mg/kg IV, then 0.5-1mg/kg/hr infusion
- Children: dosing regimens vary
Indications
- Diagnosis and treatment of vasospastic conditions
- Persistent pulmonary hypertension of the newborn
Mechanism of Action
- Alpha-adrenergic receptor antagonist
- Causes direct relaxation of smooth muscle
Contraindications
- Hypersensitivity to tolazoline
- Concurrent use with certain other medications
Adverse Reactions
- Hypotension
- Tachycardia
- Nausea
- Vomiting
- Diarrhea
Drug Interactions
- Concurrent use with beta-blockers may potentiate hypotension
- Interacts with certain anesthetics
Curated Content: Needs Vetting Before Put to Clinical Use