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CARDIOVASCULAR SYSTEM › PERIPHERAL VASODILATORS › PERIPHERAL VASODILATORS › Ergot alkaloids
dihydroergocristine
C04AE04
Forms & Strengths
- Injectable solution: 1mg/mL
- Tablets: 1mg, 2mg, 3mg
- Capsules: 1mg, 3mg
Adult Dosing
- Cerebral insufficiency: 1-3mg orally tid
- Circulatory disorders: 1-2mg IV or IM tid
- Geriatric: initial dose 0.5-1mg bid, titrate to response
Pediatric Dosing
- Not established for pediatric patients
- Use with caution in patients under 18 years
Indications
- Cerebral insufficiency and related conditions
- Dementia
- Circulatory disorders
- Raynaud's disease
- Migraine prophylaxis
Mechanism of Action
- Alpha-adrenergic agonism
- Partial serotonin agonism
- Increase in cerebral and peripheral blood flow
Contraindications
- Hypersensitivity to ergot alkaloids
- Severe hypertension
- Pheochromocytoma
- Gastrointestinal bleeding
Adverse Reactions
- Nausea and vomiting
- Abdominal pain
- Diarrhea
- Dizziness and lightheadedness
- Hypertension
Drug Interactions
- Potentiation of vasoconstrictors and sympathomimetics
- Concomitant use with beta-blockers may cause hypertension
- Interaction with macrolide antibiotics, may increase risk of ergotism
Curated Content: Needs Vetting Before Put to Clinical Use