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CARDIOVASCULAR SYSTEM › PERIPHERAL VASODILATORS › PERIPHERAL VASODILATORS › Ergot alkaloids
ergoloid mesylates, combinations
C04AE51
Forms & Strengths
- Oral sublingual tablets: 0.5 mg, 1 mg
Adult Dosing
- 1 mg orally (sublingual) three times daily
- Total daily dose: 3 mg administered in divided doses
Pediatric Dosing
- Safety and efficacy in pediatric patients have not been established
Indications
- Adjunctive relief of signs and symptoms of idiopathic decline in mental capacity in older adults
- Note: Efficacy is not established for specific dementia diagnoses such as Alzheimer's disease
Mechanism of Action
- Mixture of hydrogenated ergot alkaloids acting as alpha-adrenergic blockers
- Produces cerebral vasodilation and improves cerebral cellular metabolism
Contraindications
- Hypersensitivity to ergot alkaloids
- Presence of acute or chronic psychosis, regardless of etiology
Adverse Reactions
- Sublingual irritation
- Transient nausea
- Gastric distress
- Nasal stuffiness
- Orthostatic hypotension
- Bradycardia
Drug Interactions
- Potential additive hypotensive effects with antihypertensive agents
- Possible increased vasoconstrictive effects when combined with potent CYP3A4 inhibitors or other ergot derivatives
Curated Content: Needs Vetting Before Put to Clinical Use