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dihydroergocristine, combinations

C04AE54

Forms & Strengths

Tablets: 0.5mg + 5mg + 10mg
Injectable solution: 1mg/mL

Adult Dosing

Initial dose: 1 tablet (0.5mg + 5mg + 10mg) orally, 2-3 times a day
Maintenance dose: Adjust according to patient response
Max daily dose: 4 tablets (2mg + 20mg + 40mg)

Pediatric Dosing

Not recommended for children under 18 years
Use with caution in elderly patients

Indications

Treatment of Raynaud's phenomenon
Cerebrovascular insufficiency
Arterial occlusive disease
Migraine prophylaxis

Mechanism of Action

Alpha-adrenergic blocking activity
Beta-adrenergic stimulating activity
Vasodilation by direct action on smooth muscle

Contraindications

Hypersensitivity to ergot alkaloids
Severe coronary artery disease
Uncontrolled hypertension
Pregnancy and lactation

Adverse Reactions

Nausea and vomiting
Headache
Dizziness
Abdominal pain

Drug Interactions

Potentiated by beta-blockers
Antagonized by sympathomimetics
Concomitant use with caffeine may increase risk of adverse effects

Curated Content: Needs Vetting Before Put to Clinical Use