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kallidinogenase

C04AF01

Forms & Strengths

Injectable solution, 50 units/2ml
Injectable solution, 100 units/4ml

Adult Dosing

2ml (50 units) IV, 1-2 times a day
Start with low dose, adjust according to blood pressure response

Pediatric Dosing

Safety and efficacy not established in pediatric patients
Use with caution in pediatric patients, consider alternative treatments

Indications

Treatment of essential hypertension
Treatment of hypertension in patients with renal disease

Mechanism of Action

Conversion of kininogen to bradykinin, a vasodilator
Increases prostaglandin and nitric oxide production, reducing blood pressure

Contraindications

Hypersensitivity to kallidinogenase or any component of the formulation
Pregnancy, especially during the 1st trimester, due to potential fetal harm

Adverse Reactions

Hypotension, headache, dizziness, nausea, and vomiting
Allergic reactions, including anaphylaxis, angioedema, and rash

Drug Interactions

Concomitant use with ACE inhibitors, may increase risk of hypotension
Concomitant use with diuretics, may increase risk of dehydration and electrolyte imbalance

Curated Content: Needs Vetting Before Put to Clinical Use