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CARDIOVASCULAR SYSTEM › PERIPHERAL VASODILATORS › PERIPHERAL VASODILATORS › Other peripheral vasodilators
bencyclane
C04AX11
Forms & Strengths
- Tablets: 100 mg
- Solution for injection: 15 mg/mL
Adult Dosing
- Oral: 100 to 200 mg 2 to 3 times daily
- Intravenous/Intramuscular: 15 to 50 mg daily, administered slowly
Pediatric Dosing
- Safety and efficacy in pediatric patients not established
Indications
- Peripheral vascular disease (e.g., intermittent claudication, Raynaud's syndrome)
- Cerebrovascular insufficiency
Mechanism of Action
- Direct vascular smooth muscle relaxant acting as a papaverine-like vasodilator
- Calcium channel blocker and moderate phosphodiesterase inhibitor
- Inhibits platelet aggregation and improves erythrocyte deformability
Contraindications
- Hypersensitivity to bencyclane
- Recent myocardial infarction
- Severe acute cerebral hemorrhage
- Severe arrhythmias
- Epilepsy or history of convulsive disorders
- Severe renal or hepatic impairment
Adverse Reactions
- Gastrointestinal distress, nausea, and vomiting
- Dizziness, headache, and sleep disturbances
- Palpitations and orthostatic hypotension
- Restlessness, tremor, or anxiety
- Elevated liver enzymes
Drug Interactions
- Enhanced hypotensive effect with concurrent antihypertensive medications
- Increased risk of central nervous system side effects with sympathomimetics
- Potential potentiation of cardiac arrhythmias with other arrhythmogenic drugs
Curated Content: Needs Vetting Before Put to Clinical Use