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cinepazide

C04AX27

Forms & Strengths

Injectable solution 100 mg/2 mL
Oral tablets 100 mg
Oral tablets 200 mg

Adult Dosing

Oral: 100 to 200 mg three times daily after meals.
Intravenous/Intramuscular: 100 to 200 mg daily administered in divided doses or slow infusion for acute cerebrovascular or peripheral vascular disorders.

Pediatric Dosing

Safety and efficacy in pediatric patients have not been established; use is generally restricted to adults.

Indications

Treatment of cerebral vascular insufficiency (cerebral ischemia, sequelae of cerebrovascular accidents)
Peripheral vascular disease (intermittent claudication, Raynaud's syndrome)
Cochleovestibular disorders of vascular origin (tinnitus, vertigo)

Mechanism of Action

Acts as a vasodilator and calcium channel modulator that relaxes vascular smooth muscle.
Improves microcirculation by increasing erythrocyte deformability and reducing blood viscosity.
Enhances cerebral and peripheral blood flow without significantly altering systemic blood pressure.

Contraindications

Known hypersensitivity to cinepazide or any component of the formulation
Acute cerebral hemorrhage
Severe hypotension or shock
Recent myocardial infarction with severe hemodynamic instability

Adverse Reactions

Gastrointestinal: Nausea, vomiting, dyspepsia, epigastric discomfort
Nervous System: Dizziness, headache, drowsiness, paresthesia
Cardiovascular: Flushing, palpitations, transient hypotension
Hepatic: Transient elevation of liver transaminases
Hypersensitivity: Skin rash, pruritus

Drug Interactions

Antihypertensive agents: May enhance blood pressure-lowering effects, leading to additive hypotension.
Vasodilators: Concurrent use may increase the risk of pronounced vasodilation and associated symptoms.
Central nervous system depressants: May potentiate sedative effects.

Curated Content: Needs Vetting Before Put to Clinical Use