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CARDIOVASCULAR SYSTEM › PERIPHERAL VASODILATORS › PERIPHERAL VASODILATORS › Other peripheral vasodilators
ifenprodil
C04AX28
Forms & Strengths
- Tablets: 20mg, 40mg, 60mg, 80mg
- Injectable solution: 20mg/2mL
Adult Dosing
- 20-40mg PO tid
- Max dose: 120mg/day
- Titrate dose based on patient response
Pediatric Dosing
- Not established
- Use with caution in patients under 18 years old
Indications
- Treatment of hypertension
- Management of angina pectoris
- Vasospastic disorders
Mechanism of Action
- Selective alpha-1 adrenergic receptor antagonist
- Causes vasodilation, decreases peripheral resistance
- Reduces afterload, improves cardiac output
Contraindications
- Hypersensitivity to ifenprodil or its components
- Congestive heart failure (NYHA class III/IV)
Adverse Reactions
- Dizziness, headache, fatigue
- Nausea, vomiting, abdominal pain
- Orthostatic hypotension, peripheral edema
Drug Interactions
- Enhanced hypotension with beta-blockers, ACE inhibitors
- Increased risk of hypotension with PDE5 inhibitors
- Decreased antihypertensive effect with NSAIDs
Curated Content: Needs Vetting Before Put to Clinical Use