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CARDIOVASCULAR SYSTEM › VASOPROTECTIVES › AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE › Corticosteroids
hydrocortisone
C05AA01
Forms & Strengths
- Tablets: 5mg, 10mg, 20mg
- Injectable: 25mg/mL, 50mg/mL
- Cream: 0.5%, 1%, 2.5%
- Ointment: 0.5%, 1%, 2.5%
- Rectal foam: 10%
- Rectal suppository: 25mg
Adult Dosing
- Allergic reactions: 20-240mg/day PO
- Adrenal insufficiency: 20-30mg/day PO
- Rheumatic disorders: 20-240mg/day PO
- Dermatologic diseases: apply topical 1-4 times/day
Pediatric Dosing
- Allergic reactions: 1-4mg/kg/day PO
- Adrenal insufficiency: 10-20mg/m2/day PO
- Dermatologic diseases: apply topical 1-4 times/day
Indications
- Adrenal insufficiency
- Allergic reactions
- Rheumatic disorders
- Dermatologic diseases
- Respiratory disorders
- Hematologic disorders
Mechanism of Action
- Corticosteroid receptor agonist
- Inhibits inflammatory cells
- Suppresses immune response
- Affects glucose metabolism
Contraindications
- Hypersensitivity to hydrocortisone
- Intramuscular injection in idiopathic thrombocytopenic purpura
- Live or attenuated vaccines
- Active infections
Adverse Reactions
- Hypertension
- Glucose intolerance
- Osteoporosis
- Weight gain
- Cushing's syndrome
- Adrenal suppression
- Skin atrophy
Drug Interactions
- Warfarin: decreased anticoagulant effect
- Aspirin: increased risk of GI bleeding
- Phenobarbital: decreased hydrocortisone effect
- Cyclosporine: increased risk of seizures
- Ketoconazole: increased hydrocortisone effect
Curated Content: Needs Vetting Before Put to Clinical Use