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fluorometholone

C05AA06

Forms & Strengths

Ophthalmic suspension 0.1%
Ophthalmic suspension 0.25%

Adult Dosing

Instill 1 to 2 drops into the conjunctival sac two to four times daily
During the initial 24 to 48 hours, dosing may be increased to every 2 hours as needed

Pediatric Dosing

Safety and efficacy in pediatric patients below 2 years of age have not been established
Children 2 years and older: Instill 1 to 2 drops into the conjunctival sac two to four times daily

Indications

Treatment of corticosteroid-responsive inflammation of the palpal and bulbar conjunctiva, cornea, and anterior segment of the globe

Mechanism of Action

Synthetic corticosteroid that diffuses through cell membranes and complexes with cytosolic glucocorticoid receptors
Suppresses the immune response by inhibiting multiple inflammatory cytokines, reducing edema, fibrin deposition, capillary dilation, leukocyte migration, capillary proliferation, fibroblast proliferation, and scar formation

Contraindications

Most viral diseases of the cornea and conjunctiva including epithelial herpes simplex keratitis (dendritic keratitis), vaccinia, and varicella
Mycobacterial infection of the eye
Fungal diseases of ocular structures
Hypersensitivity to any component of the medication

Adverse Reactions

Elevated intraocular pressure with possible optic nerve damage, visual acuity and field defects
Posterior subcapsular cataract formation
Secondary ocular infection from pathogens suppressed by host defenses
Delayed wound healing
Transient stinging or burning upon instillation

Drug Interactions

Concomitant use of anticholinergics may increase intraocular pressure
Prolonged concurrent use of topical ophthalmic NSAIDs and corticosteroids may delay corneal healing

Curated Content: Needs Vetting Before Put to Clinical Use