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CARDIOVASCULAR SYSTEM › VASOPROTECTIVES › AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE › Corticosteroids
triamcinolone
C05AA12
Forms & Strengths
- Cream 0.1%
- Ointment 0.1%
- Lotion 0.1%
- Paste 0.1%
- Injectable suspension 10mg/mL
- Injectable suspension 40mg/mL
- Aerosol 0.0147%
- Tablets 4mg
Adult Dosing
- Apply topical forms 2-3 times daily
- Injectable suspension 2.5-5mg for intra-articular use
- Injectable suspension 5-40mg for intramuscular use
- Oral tablets 4-48mg daily in divided doses
Pediatric Dosing
- Apply topical forms 2-3 times daily for children over 6 years
- Injectable suspension for children under 6 years is not recommended
- For children over 6 years, use adult dosing with caution
Indications
- Allergic dermatitis
- Psoriasis
- Eczema
- Lichen planus
- Seborrheic dermatitis
- Intra-articular or periarticular inflammatory conditions
- Asthma
- Allergic rhinitis
Mechanism of Action
- Triamcinolone is a synthetic glucocorticoid with anti-inflammatory activity
- It inhibits multiple inflammatory pathways
- It suppresses the immune response
Contraindications
- Hypersensitivity to triamcinolone or other corticosteroids
- Intramuscular administration in idiopathic thrombocytopenic purpura
- Live or attenuated vaccines in patients on immunosuppressive doses
- Fungal or bacterial infections of the skin or eye
Adverse Reactions
- Skin atrophy
- Telangiectasia
- Hypopigmentation
- Moon face
- Weight gain
- Hypertension
- Glaucoma with topical eye administration
- Cushing syndrome
Drug Interactions
- CYP3A4 inhibitors increase the risk of Cushing syndrome
- Live or attenuated vaccines may have decreased efficacy
- Warfarin and other anticoagulants may increase the risk of bleeding
- Corticosteroids may decrease the efficacy of somatrem or somatropin
Curated Content: Needs Vetting Before Put to Clinical Use