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CARDIOVASCULAR SYSTEM › VASOPROTECTIVES › AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE › Local anesthetics
cinchocaine
C05AD04
Forms & Strengths
- Topical cream 5%
- Topical ointment 5%
- Rectal suppository 0.5mg-1mg
Adult Dosing
- Apply 1-2g of 5% cream to affected area 3-4 times daily
- Insert 1 suppository rectally 1-2 times daily
Pediatric Dosing
- Not recommended for children under 12 years
- For children over 12 years, apply 1g of 5% cream to affected area 2-3 times daily
Indications
- Relief of pruritus and pain associated with hemorrhoids
- Treatment of anal fissures and proctitis
- Relief of itching and pain in pruritus ani
Mechanism of Action
- Acts as a local anesthetic by blocking sodium channels
- Produces vasodilation and inhibits release of histamine and other chemical mediators
Contraindications
- Hypersensitivity to cinchocaine or other amide local anesthetics
- Not recommended for children under 12 years due to risk of methemoglobinemia
Adverse Reactions
- Local irritation, redness, and itching at application site
- Allergic reactions such as hives, swelling, and difficulty breathing
- Methemoglobinemia in rare cases, especially in children and infants
Drug Interactions
- Interacts with other local anesthetics, increasing risk of systemic toxicity
- May interact with class III anti-arrhythmics, increasing risk of cardiotoxicity
Curated Content: Needs Vetting Before Put to Clinical Use