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CARDIOVASCULAR SYSTEM › VASOPROTECTIVES › AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE › Other agents for treatment of hemorrhoids and anal fissures for topical use
tribenoside
C05AX05
Forms & Strengths
- Cream 5%
- Suppositories 400 mg
- Oral tablets 400 mg
Adult Dosing
- Hemorrhoids (topical): Apply cream 1-2 times daily
- Hemorrhoids (suppositories): Insert 1 suppository twice daily
- Chronic venous insufficiency: 400 mg orally twice daily
Pediatric Dosing
- Safety and efficacy not established in pediatric patients
Indications
- Internal and external hemorrhoids
- Perianal venous congestion
- Chronic venous insufficiency of the lower extremities
Mechanism of Action
- Acts as a local vascular-protecting agent
- Reduces vascular permeability and improves microcirculation tone
- Exerts local anti-inflammatory and analgesic effects on hemorrhoidal tissue
Contraindications
- Hypersensitivity to tribenoside, lidocaine (if combination product), or excipients
- Severe hepatic impairment
Adverse Reactions
- Local burning sensation or irritation at application site
- Pruritus
- Allergic skin reactions
- Mild gastrointestinal disturbances (oral administration)
Drug Interactions
- No clinically significant pharmacokinetic drug interactions reported
- Avoid concurrent application of other topical anorectal preparations in the same area
Curated Content: Needs Vetting Before Put to Clinical Use