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CARDIOVASCULAR SYSTEM › VASOPROTECTIVES › ANTIVARICOSE THERAPY › Heparins or heparinoids for topical use
pentosan polysulfate sodium
C05BA04
Adult Dosing
- Interstitial cystitis: 100 mg orally three times daily, taken with water 1 hour before or 2 hours after meals
Pediatric Dosing
- Safety and efficacy not established in pediatric patients under 16 years of age
Indications
- Relief of bladder pain or discomfort associated with interstitial cystitis
Mechanism of Action
- Low-molecular-weight heparinoid; adheres to the bladder wall mucosal membrane, acting as a buffer to protect permeability against irritating solutes in urine
Contraindications
- Known hypersensitivity to pentosan polysulfate sodium or heparin
- Conditions with increased risk or history of bleeding (e.g., major surgery, hemophilia, thrombocytopenia, GI ulcerations)
Adverse Reactions
- Common: Alopecia, diarrhea, nausea, headache, dyspepsia, abdominal pain
- Serious: Bleeding complications, thrombocytopenia, liver function abnormalities, pigmentary maculopathy (chronic use)
Drug Interactions
- Anticoagulants (e.g., warfarin, heparin) and antiplatelet agents (e.g., NSAIDs, aspirin): Increased risk of hemorrhage
Curated Content: Needs Vetting Before Put to Clinical Use