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calcium dobesilate

C05BX01

Forms & Strengths

Oral capsules: 500 mg

Adult Dosing

Chronic venous insufficiency: 500 mg orally 2 to 3 times daily with meals
Diabetic retinopathy: 500 mg orally 3 times daily with meals

Pediatric Dosing

Safety and efficacy not established in pediatric patients

Indications

Treatment of chronic venous insufficiency and associated symptoms
Management of diabetic retinopathy

Mechanism of Action

Reduces capillary resistance and increases vascular permeability
Inhibits platelet aggregation and blood viscosity
Reduces edema by decreasing capillary hyperpermeability

Contraindications

Hypersensitivity to calcium dobesilate or excipients
Severe renal impairment requiring dialysis

Adverse Reactions

Gastrointestinal disturbances (nausea, diarrhea)
Skin reactions (rash, pruritus)
Fever
Agranulocytosis (rare, reversible upon discontinuation)

Drug Interactions

Potential enhancement of oral anticoagulant effects
No major clinically significant pharmacokinetic drug-drug interactions documented

Curated Content: Needs Vetting Before Put to Clinical Use