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calcium dobesilate, combinations

C05BX51

Forms & Strengths

Oral capsule: Calcium dobesilate 250 mg / 500 mg (often combined with agents like troxerutin or essential phospholipids)

Adult Dosing

Chronic venous insufficiency: 500 mg orally 2 to 3 times daily with meals
Diabetic retinopathy: 500 mg orally 3 times daily
Hemorrhoids: 500 mg orally 3 times daily during acute episodes

Pediatric Dosing

Safety and efficacy in pediatric patients have not been established

Indications

Treatment of chronic venous insufficiency and related symptoms (leg pain, cramps, edema)
Management of diabetic retinopathy
Treatment of hemorrhoids

Mechanism of Action

Reduces vascular permeability and increases capillary resistance
Improves lymphatic drainage and microcirculation
Inhibits platelet aggregation and blood hyperviscosity

Contraindications

Hypersensitivity to calcium dobesilate or any component in the combination
Severe renal impairment requiring dialysis
First trimester of pregnancy (relative contraindication)

Adverse Reactions

Gastrointestinal disturbances (nausea, diarrhea, epigastric pain)
Agammaglobulinemia/neutropenia (rare, reversible)
Skin rashes and allergic reactions
Fever and arthralgia

Drug Interactions

Potential enhancement of oral anticoagulant effects (e.g., warfarin)
May increase plasma levels of certain drugs cleared via renal tubular secretion
No major cytochrome P450-mediated drug interactions identified

Curated Content: Needs Vetting Before Put to Clinical Use