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CARDIOVASCULAR SYSTEM › VASOPROTECTIVES › CAPILLARY STABILIZING AGENTS › Bioflavonoids
rutoside
C05CA01
Forms & Strengths
- Oral tablets: 500 mg
- Capsules: 250 mg
- Topical gel: 2%
Adult Dosing
- Chronic venous insufficiency: 500 mg orally twice daily
- Hemorrhoids: 1000 mg daily in divided doses
- Topical: Apply thin layer to affected area 2-3 times daily
Pediatric Dosing
- Safety and efficacy not established in pediatric patients
Indications
- Relief of symptoms related to chronic venous insufficiency (leg pain, heaviness, nocturnal cramps)
- Adjunctive treatment of acute hemorrhoidal attacks
- Management of capillary fragility and edema
Mechanism of Action
- Increases vascular tone and protects microcirculation
- Reduces capillary permeability and prevents fluid filtration into interstitial spaces
- Exhibits antioxidant and anti-inflammatory properties by scavenging free radicals and inhibiting inflammatory mediators
Contraindications
- Hypersensitivity to rutoside or related flavonoids (e.g., rutin)
- Severe renal impairment (safety not established)
Adverse Reactions
- Mild gastrointestinal distress (nausea, epigastric pain)
- Allergic skin reactions (rash, pruritus)
- Headache or dizziness (rare)
Drug Interactions
- May theoretically enhance the absorption of vitamin C
- No major clinically significant pharmacokinetic drug interactions documented
Curated Content: Needs Vetting Before Put to Clinical Use