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diosmin

C05CA03

Forms & Strengths

Oral tablets: 500 mg, 600 mg
Micronized purified flavonoid fraction (MPFF): 90% diosmin, 10% hesperidin (450 mg / 50 mg or 540 mg / 60 mg)

Adult Dosing

Chronic venous insufficiency: 500 mg twice daily (or 1000 mg once daily)
Acute hemorrhoidal attack: 1000 mg 3 times daily for 4 days, then 1000 mg twice daily for 3 days
Chronic hemorrhoids: 500 mg twice daily

Pediatric Dosing

Safety and efficacy not established in pediatric patients (<18 years)

Indications

Chronic venous insufficiency (CVI) of the lower limbs (e.g., pain, leg cramps, edema)
Acute and chronic hemorrhoidal disease

Mechanism of Action

Venoactive agent that increases venous tone by prolonging the vasoconstrictor effect of norepinephrine on the vessel wall
Reduces venous distensibility and venous stasis
Protects microcirculation by reducing capillary permeability and increasing lymphatic drainage
Exerts anti-inflammatory effects by inhibiting leukocyte adhesion, migration, and activation

Contraindications

Hypersensitivity to diosmin, hesperidin, or any components of the formulation
Severe renal or hepatic impairment (lack of safety data)

Adverse Reactions

Gastrointestinal: mild diarrhea, nausea, dyspepsia, abdominal pain
Nervous system: headache, dizziness, vertigo
Dermatological: rash, pruritus, urticaria

Drug Interactions

Metronidazole: may decrease metabolism or increase plasma levels (theoretical)
CYP3A4 substrates: mild inhibitor potential, though clinical significance is generally low at standard doses

Curated Content: Needs Vetting Before Put to Clinical Use