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Hippocastani semen

C05CX03

Forms & Strengths

Standardized seed extract capsules (typically 250-300 mg, equivalent to 50 mg aescin)
Topical gels and creams (usually 2% aescin)

Adult Dosing

Oral: 50 mg aescin (approx. 250-300 mg standardized extract) twice daily
Topical: Apply gel/cream to affected area 3-4 times daily

Pediatric Dosing

Safety and efficacy not established in pediatric patients under 18 years

Indications

Chronic venous insufficiency (CVI)
Varicose veins
Leg heaviness, pain, and nocturnal cramping
Post-operative or post-traumatic edema

Mechanism of Action

Inhibits lysosomal enzymes (hyaluronidase, elastase) that degrade the endothelial glycocalyx of capillary walls
Reduces vascular permeability, preventing fluid filtration into the interstitial space
Increases venous tone via prostaglandin F2alpha release

Contraindications

Known hypersensitivity to horse chestnut (Aesculus hippocastanum) or related plants
Severe renal impairment
Severe hepatic impairment
Pregnancy and lactation due to insufficient safety data

Adverse Reactions

Gastrointestinal upset (nausea, dyspepsia)
Pruritus
Dizziness
Headache
Allergic contact dermatitis (with topical application)

Drug Interactions

Potential enhancement of anticoagulant and antiplatelet agents (warfarin, aspirin) due to theoretical bleeding risk
May potentially increase nephrotoxicity when combined with aminoglycoside antibiotics

Curated Content: Needs Vetting Before Put to Clinical Use